ampicillin sodium

2024-04-23by admin0

Ampicillin sodium structural formula

Structural formula

Business number 01FN
Molecular formula C16H18N3NaO4S
Molecular weight 371.38
label

ampicillin sodium,

(2S,5R,6R)-3,3-dimethyl-6-[(R)-2-amino-2-phenylacetamido]-7-oxo-4-thia-1-azabicyclo[ 3.2.0]Heptane-2-carboxylic acid sodium salt,

Sodium [2S-[2α,5α,6β(S*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate ,

D-(-)-α-Aminobenzylpenicillin sodium salt

Numbering system

CAS number:69-52-3

MDL number:MFCD00064313

EINECS number:200-708-1

RTECS number:XH8400000

BRN number:4119211

PubChem number:24891463

Physical property data

1. Characteristics: White or off-white powder or crystal. Odorless or slightly odorless, slightly bitter in taste.


2. Density ( g/mL,25/4): Undetermined


3. Relative vapor density (g/mL,Air=1): Undetermined


4. Melting point ( ºC): 205(decomposition)


5. Boiling point ( ºC,Normal pressure): Undetermined


6. Boiling point ( ºC,5.2kPa): Undetermined


7. Refractive Index: Undetermined


8. Flashpoint (ºC): Undetermined


9. Specific optical rotation (º,C0.2, in the water):+209°


10. Autoignition point or ignition temperature (ºC): Not OK


11. Vapor pressure (kPa,25ºC): Undetermined


12. Saturation vapor pressure (kPa,60ºC): Undetermined


13. heat of combustion (KJ/mol): Undetermined


14. Critical temperature (ºC): Undetermined


15. Critical Pressure (KPa): Undetermined


16. Oil and water (octanol/Water) partition coefficient pair Number�:Undetermined


17. Explosion limit (%,V/V): Not OK


18. Lower explosion limit (%,V/V): Not OK


19. Solubility:Yes Hygroscopic. Easily soluble in water, slightly soluble in acetone and ethanol, slightly soluble in chloroform, insoluble in ether.

Toxicological data


Acute toxicity: women’s oral administrationLDLo100 mg/kg/5D ;Rat Oral PeriodLD50>5314 mg/kg;Rat abdominal cavityLD507400 mg/kg ;
Rat subcutaneous injectionLD50>5314 mg/kg; Mouse caliberLD50>5314 mg/kg;Mouse abdominal cavityLD505700 mg/kg;
Mouse subcutaneous injectionLD50>5314 mg/kg; Rat veinLDLo 2657 mg/kg;

Ecological data

None

Molecular structure data

None

Compute chemical data

1. Hydrogen Bonding Number of donors: 2


2. Hydrogen Bonding Number of receptors: 5


3. Rotatable Number of chemical bonds: 4


4. Interchange Number of isomers: 2


5. Topological molecules Polar surface area (TPSA):116


6. Heavy atoms Quantity: 25


7. Surface charge :0


8. Complexity :568


9. Isotope atomic number:0


10. Determine the number of atomic stereocenters:4


11. Uncertain number of atomic stereocenters:0


12. Determine the number of stereocenters of chemical bonds:0


13. Uncertain number of chemical bond stereocenters:0


14. Number of covalent bond units: 2

Properties and stability

None

Storage method


This product should be sealed in4Preserve dry. Validity period2year and a half.


Synthesis method

Obtained from the salt formation of ampicillin: suspend ampicillin in water and adjust with sodium hydroxide solutionpHto9, dissolve, filter. Add activated carbon to the filtrate to decolorize, filter, and dry the filtrate at low temperature to obtain the product.

Purpose


For molecular biology and tissue culture (to prevent microbial contamination).


Ampicillin sodium-basedThe bactericidal ingredients in �� act on the active reproduction stage of bacteria and exert a bactericidal effect by inhibiting the biosynthesis of cell wall mucopeptides.

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